Antiviral Profiling of C-18- or C-19-Functionalized Semisynthetic Abietane Diterpenoids.

ABSTRACT: Viral infections affect several million patients annually. Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy may be a proper alternative for treating viral diseases. Several natural and semisynthetic abietane-type diterpenoids have shown important antiviral activities. In this study, a biological evaluation of a number of either C-18- or C-19-functionalized known semisynthetic abietanes against Zika virus, Dengue virus, Herpes virus simplex type 1, and Chikungunya virus are reported. Semisynthetic abietane ferruginol and its analogue 18-(phthalimid-2-yl)ferruginol displayed broad-spectrum antiviral properties. The scale-up synthesis of this analo

SUBMITTER: Gonzalez-Cardenete MA 

PROVIDER: S-EPMC9425435 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature