Common maternal infections during pregnancy and childhood leukaemia in the offspring: findings from six international birth cohorts.

ABSTRACT:

Background

Previous epidemiological studies have found positive associations between maternal infections and childhood leukaemia; however, evidence from prospective cohort studies is scarce. We aimed to examine the associations using large-scale prospective data.

Methods

Data were pooled from six population-based birth cohorts in Australia, Denmark, Israel, Norway, the UK and the USA (recruitment 1950s-2000s). Primary outcomes were any childhood leukaemia and acute lymphoblastic leukaemia (ALL); secondary outcomes were acute myeloid leukaemia (AML) and any childhood cancer. Exposures included maternal self-reported infections [influenza-like illness, common cold, any respiratory tract infection, vaginal thrush, vaginal infections and urinary tract infection (including cystit

SUBMITTER: He JR 

PROVIDER: S-EPMC9425514 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature