Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism.

ABSTRACT:

Introduction

Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance.

Methods

Patients diagnosed with pulmonary tuberculosis (75), volunteers with positive tuberculin skin test (70) and healthy volunteers with negative tuberculin skin test and no history of contact with tuberculosis (57) were evaluated regarding the IFNG+874 genotype and the

SUBMITTER: Carneiro VL 

PROVIDER: S-EPMC9425666 | biostudies-literature | 2018 May - Jun

REPOSITORIES: biostudies-literature