The prognostic value of immune-related genes AZGP1, SLCO5A1, and CTF1 in Uveal melanoma.

ABSTRACT:

Objective

Uveal melanoma (UM) is an aggressive malignancy with a poor prognosis and no available effective treatment. Therefore, exploring a potential prognostic marker for UM could provide new possibilities for early detection, recurrence, and treatment.

Methods

In this study, we used "ConsensusClusterPlus" to classify patients with UM into subgroups, screened for significant differences in immune prognostic factors between subgroups, selected three genes using LASSO (Least absolute shrinkage and selection operator) regression to construct a risk model, and performed tumor immune cell infiltration analysis on the risk model. infiltration analysis, and then verified the heterogeneous role of the 3 core genes in other cancers by pan-cancer analysis and validate its expression

SUBMITTER: Wang W 

PROVIDER: S-EPMC9425775 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature