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Fundamental understanding of the size and surface modification effects on r ₁, the relaxivity of Prussian blue nanocube@m-SiO₂: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer.

ABSTRACT: A targeted multimodal strategy on a single nanoplatform is attractive in the field of nanotheranostics for the complete ablation of cancer. Herein, we have designed mesoporous silica (m-SiO₂)-coated Prussian blue nanocubes (PBNCs), functionalized with hyaluronic acid (HA) to construct a multifunctional PBNC@m-SiO₂@HA nanoplatform that exhibited good biocompatibility, excellent photodynamic activity, and in vitro T ₁-weighted magnetic resonance imaging ability (r ₁ ∼ 3.91 mM^-1 s^-1). After loading doxorubicin into the as-prepared PBNC@m-SiO₂@HA, the developed PBNC@m-SiO₂@HA@DOX displayed excellent pH-responsive drug release characteristics. Upon irradiation with 8

SUBMITTER: Sahoo P

PROVIDER: S-EPMC9425834 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Fundamental understanding of the size and surface modification effects on r ₁, the relaxivity of Prussian blue nanocube@m-SiO₂: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Fundamental understanding of the size and surface modification effects on r 1, the relaxivity of Prussian blue nanocube@m-SiO2: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Fundamental understanding of the size and surface modification effects on r ₁, the relaxivity of Prussian blue nanocube@m-SiO₂: a novel targeted chemo-photodynamic theranostic agent to treat colon cancer.