Immunogenicity of SARS-CoV-2 vaccines in patients with breast cancer.

ABSTRACT:

Purpose

To explore the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with breast cancer based on type of anticancer treatment.

Methods

Patients with breast cancer had anti-spike antibody concentrations measured ⩾14 days after receiving a full SARS-CoV-2 vaccination series. The primary endpoint was IgA/G/M anti-spike antibody concentration. Multiple regression analysis was used to analyze log₁₀-transformed antibody titer concentrations.

Results

Between 29 April and 20 July 2021, 233 patients with breast cancer were enrolled, of whom 212 were eligible for the current analysis. Patients who received mRNA-1273 (Moderna) had the highest antibody concentrations [geometric mean concentration (GMC) in log₁₀

SUBMITTER: Denault E 

PROVIDER: S-EPMC9425892 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature