The effect of general anesthesia on the test-retest reliability of resting-state fMRI metrics and optimization of scan length.

ABSTRACT: Resting-state functional magnetic resonance imaging (rs-fMRI) has been known as a powerful tool in neuroscience. However, exploring the test-retest reliability of the metrics derived from the rs-fMRI BOLD signal is essential, particularly in the studies of patients with neurological disorders. Here, two factors, namely, the effect of anesthesia and scan length, have been estimated on the reliability of rs-fMRI measurements. A total of nine patients with drug-resistant epilepsy (DRE) requiring interstitial thermal therapy (LITT) were scanned in two states. The first scan was performed in an awake state before surgery on the same patient. The second scan was performed 2 weeks later under general anesthesia necessary for LITT surgery. At each state, two rs-fMRI sessions were obtained that eac

SUBMITTER: Vedaei F 

PROVIDER: S-EPMC9425911 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature