Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.

ABSTRACT:

Background

Patients with autism spectrum disorder (ASD) experience high rates of sleep disruption beginning early in life; however, the developmental consequences of this disruption are not understood. We examined sleep behavior and the consequences of sleep disruption in developing mice bearing C-terminal truncation mutation in the high-confidence ASD risk gene SHANK3 (Shank3ΔC). We hypothesized that sleep disruption may be an early sign of developmental divergence, and that clinically relevant Shank3^WT/ΔC mice may be at increased risk of lasting deleterious outcomes following early life sleep disruption.

Methods

We recorded sleep behavior in developing Shank3^ΔC/ΔC, Shank3^WT/ΔC, and wild-type siblings of both sexes using a noninvasive home-c

SUBMITTER: Lord JS 

PROVIDER: S-EPMC9425965 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature