Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions.

ABSTRACT:

Background

Evolutionary rate is a key characteristic of gene families that is linked to the functional importance of the respective genes as well as specific biological functions of the proteins they encode. Accurate estimation of evolutionary rates is a challenging task that requires precise phylogenetic analysis. Here we present an easy to estimate protein family level measure of sequence variability based on alignment column homogeneity in multiple alignments of protein sequences from Clade-Specific Clusters of Orthologous Genes (csCOGs).

Results

We report genome-wide estimates of variability for 8 diverse groups of bacteria and archaea and investigate the connection between variability and various genomic and biological features. The variability estimates are based on ho

SUBMITTER: Karamycheva S 

PROVIDER: S-EPMC9425974 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature