Haematological profile of malaria patients with G6PD and PKLR variants (erythrocytic enzymopathies): a cross-sectional study in Thailand.

ABSTRACT:

Background

Glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PKLR) deficiencies are common causes of erythrocyte haemolysis in the presence of antimalarial drugs such as primaquine and tafenoquine. The present study aimed to elucidate such an association by thoroughly investigating the haematological indices in malaria patients with G6PD and PKLR^R41Q variants.

Methods

Blood samples from 255 malaria patients from Thailand, Myanmar, Laos, and Cambodia were collected to determine haematological profile, G6PD enzyme activity and G6PD deficiency variants. The multivariate analysis was performed to investigate the association between anaemia and G6PD Mahidol^G487A, the most common mutation in this study.

Results

The prevalence of G6PD defici

SUBMITTER: Mungkalasut P 

PROVIDER: S-EPMC9426002 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature