A novel knowledge-based prediction model for estimating an initial equivalent uniform dose in semi-auto-planning for cervical cancer.

ABSTRACT:

Background

We developed a novel concept, equivalent uniform length (EUL), to describe the relationship between the generalized equivalent uniform dose (EUD) and the geometric anatomy around a tumor target. By correlating EUL with EUD, we established two EUD-EUL knowledge-based (EEKB) prediction models for the bladder and rectum that predict initial EUD values for generating quality treatment plans.

Methods

EUL metrics for the rectum and bladder were extracted and collected from the intensity-modulated radiotherapy therapy (IMRT) plans of 60 patients with cervical cancer. The two EEKB prediction models were built using linear regression to establish the relationships between EUL_r and EUD_r (EUL and EUD of rectum) and EUL_b, and EUD_b (

SUBMITTER: Tao C 

PROVIDER: S-EPMC9426003 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature