Theileria annulata SVSP455 interacts with host HSP60.

ABSTRACT:

Background

Theileria annulata, a transforming parasite, invades bovine B cells, dendritic cells and macrophages, promoting the uncontrolled proliferation of these cells. This protozoan evolved intricate strategies to subvert host cell signaling pathways related to antiapoptotic signaling to enable survival and proliferation within the host cells. However, the molecular mechanisms of the cell transformation induced by T. annulata remain largely unclear. Although some studies have predicted that the subtelomere-encoded variable secreted protein (SVSP) family plays roles in host-parasite interactions, the evidence for this is limited.

Methods

In the present study, the SVSP455 (TA05545) gene, a member of the SVSP gene family, was used as the target molecule. The expression patte

SUBMITTER: Li Z 

PROVIDER: S-EPMC9426020 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature