Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression.

ABSTRACT:

Objective

To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.

Methods

We collected clinical data from patients with invasive breast cancer from 2010 to 2020 in the First affiliated hospital of Nanchang University, evaluated the prognostic value of VDAC1 gene expression in breast cancer, and detected the expression of VDAC1 protein in breast cancer tissues and paracancerous tissues by immunohistochemical staining of paraffin sections. Also, we cultured breast cancer cells (MCF-7) to observe the effect of lidocaine on the apoptosis of MCF-7 cells.

Results

Analysis of clinical data and gene expression data of BRCA patients showed V

SUBMITTER: Long D 

PROVIDER: S-EPMC9426218 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature