Lipid signatures of chronic pain in female adolescents with and without obesity.

ABSTRACT:

Background

Chronic pain in adolescence is associated with diminished outcomes, lower socioeconomic status in later life, and decreased family well-being. Approximately one third of adolescents with chronic pain have obesity compared to the general population. In obesity, lipid signals regulate insulin sensitivity, satiety, and pain sensation. We determined whether there is a distinct lipid signature associated with chronic pain and its co-occurrence with obesity in adolescents.

Methods

We performed global lipidomics in serum samples from female adolescents (N = 67, 13-17 years old) with no pain/healthy weight (Controls), chronic pain/healthy weight (Pain Non-obese), no pain/obesity (Obese), or chronic pain/obesity (Pain Obese).

Results

The Pain Non-obese group had lip

SUBMITTER: Gonzalez PA 

PROVIDER: S-EPMC9426222 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature