Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) play a functional role in the progression of prostate cancer (PCa). However, the molecular mechanism, expression, or function of the lncRNA XIST in PCa is not well understood. Therefore, the major goal of this study was to investigate the involvement of XIST in PCa.

Methods

We used the The Cancer Genome Atlas (TCGA) database to conduct a pan-cancer bioinformatics analysis of XIST and identified that it may play an important role in prostate cancer. This finding was verified using clinical samples and in vitro assays. Finally, we constructed an XIST ceRNA network for prostate cancer.

Results

Our in vitro and in vivo results showed that the XIST gene expression level was higher in PCa derived cells and tissues compared to that i

SUBMITTER: Wang J 

PROVIDER: S-EPMC9426231 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature