Progression of Alzheimer's disease parallels unusual structural plasticity of human dentate granule cells.

ABSTRACT: Alzheimer´s disease (AD), the most common form of dementia in industrialized countries, severely targets the hippocampal formation in humans and mouse models of this condition. The adult hippocampus hosts the continuous addition of new dentate granule cells (DGCs) in numerous mammalian species, including humans. Although the morphology and positioning of DGCs within the granule cell layer (GCL) match their developmental origin in rodents, a similar correlation has not been reported in humans to date. Our data reveal that DGCs located in inner portions of the human GCL show shorter and less complex dendrites than those found in outer portions of this layer, which are presumably generated developmentally. Moreover, in AD patients, DGCs show early morphological alterations that are further ag

SUBMITTER: Marquez-Valadez B 

PROVIDER: S-EPMC9426249 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature