Approach to Resectable N1 Non-Small Cell Lung Cancer: An Analysis of the National Cancer Database.

ABSTRACT:

Background

In patients with clinical N1 disease, minimally invasive surgery (MIS) has potentially better perioperative outcome compared to open thoracotomy. Additionally, whether adjuvant or neoadjuvant chemotherapy produces the best long-term survival is still debatable.

Methods

We queried The National Cancer Database for patients with clinical N1 NSCLC who underwent surgical resection between 2010 and 2014. Comparison between patients receiving MIS and patients who underwent open thoracotomy was done using an intention-to-treat analysis. Comparison was also done among neoadjuvant, adjuvant chemotherapy, and only surgery. Proportional hazard models were used to evaluate the effects of surgical approach and timing of chemotherapy on overall survival.

Results

A total o

SUBMITTER: Pu CY 

PROVIDER: S-EPMC9426286 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature