Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver-resident NK cells.

ABSTRACT: The effects of acute portal hypertension (PHT), which is reported as poor prognostic factors in patients with hepatocellular carcinoma, are not well known on the liver immune system, including natural killer (NK) cells. The aim of this study, therefore, was to investigate how acute PHT influences the functions and characteristics of liver-resident NK (lr-NK) cells using an acute PHT mouse model. Acute PHT decreased the number of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL⁺ ) lr-NK cells by about 20% and attenuated cytotoxic activity against the Hepa1-6 cell line by about 40%. Among various cytokine, only interleukin-33 (IL-33), which inhibits NK activity, significantly increased after portal vein ligation (PVL). Because lr-NK cells highly expressed ST2/IL-33R,

SUBMITTER: Imaoka Y 

PROVIDER: S-EPMC9426399 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature