CroR Regulates Expression of <i>pbp4(5)</i> to Promote Cephalosporin Resistance in Enterococcus faecalis.

ABSTRACT: Enterococcus faecalis is an opportunistic pathogen and a major cause of severe nosocomial infections. Treatment options against enterococcal infections are declining due to the resistance of enterococci to numerous antibiotics. A key risk factor for developing enterococcal infections is treatment with cephalosporin antibiotics, to which enterococci are intrinsically resistant. For susceptible organisms, cephalosporins inhibit bacterial growth by acylating the active site of penicillin-binding proteins (PBPs), key enzymes that catalyze peptidoglycan cross-linking. Two specific PBPs of enterococci, Pbp4(5) and PbpA(2b), exhibit low reactivity toward cephalosporins, allowing these PBPs to cross-link peptidoglycan in the presence of cephalosporins to drive resistance in enterococci, but the me

SUBMITTER: Timmler SB 

PROVIDER: S-EPMC9426447 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature