The Gut Bacterial Community Potentiates Clostridioides difficile Infection Severity.

ABSTRACT: The severity of Clostridioides difficile infections (CDI) has increased over the last few decades. Patient age, white blood cell count, and creatinine levels as well as C. difficile ribotype and toxin genes have been associated with disease severity. However, it is unclear whether specific members of the gut microbiota are associated with variations in disease severity. The gut microbiota is known to interact with C. difficile during infection. Perturbations to the gut microbiota are necessary for C. difficile to colonize the gut. The gut microbiota can inhibit C. difficile colonization through bile acid metabolism, nutrient consumption, and bacteriocin production. Here, we sought to demonstrate that members of the gut bacterial communities can also contribute to disease severity. We deriv

SUBMITTER: Lesniak NA 

PROVIDER: S-EPMC9426473 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature