Identification and Characterization of Major Bile Acid 7α-Dehydroxylating Bacteria in the Human Gut.

ABSTRACT: The metabolism of bile acids (BAs) by gut bacteria plays an important role in human health. This study identified and characterized 7α-dehydroxylating bacteria, which are majorly responsible for converting primary BAs to secondary BAs, in the human gut and investigated their association with human disease. Six 7α-dehydratase (BaiE) clusters were identified from human gut metagenomes through sequence similarity network and genome neighborhood network analyses. Abundance analyses of gut metagenomes and metatranscriptomes identified a cluster of bacteria (cluster 1) harboring baiE genes that may be key 7α-dehydroxylating bacteria in the human gut. The baiE gene abundance of cluster 1 was significantly and positively correlated with the ratio of secondary BAs to primary BAs. Furt

SUBMITTER: Kim KH 

PROVIDER: S-EPMC9426597 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature