Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3⁺ /CD141⁺ ) dendritic cells.

ABSTRACT: Dendritic cells (DCs) bridge the connection between innate and adaptive immunity. DCs present antigens to T cells and stimulate potent cytotoxic T-cell responses. Metabolic reprogramming is critical for DC development and activation; however, metabolic adaptations and regulation in DC subsets remains largely uncharacterized. Here, we mapped metabolomic and lipidomic signatures associated with the activation phenotype of human conventional DC type 1, a DC subset specialized in cross-presentation and therefore of major importance for the stimulation of CD8⁺ T cells. Our metabolomics and lipidomic analyses showed that Toll-like receptor (TLR) stimulation altered glycerolipids and amino acids in cDC1. Poly I:C or pRNA stimulation reduced triglycerides and cholesterol esters, as well

SUBMITTER: Basit F 

PROVIDER: S-EPMC9426619 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature