Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife.

ABSTRACT:

Objective

Cannabis use is increasing among midlife and older adults. This study tested the hypotheses that long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife, which is important because midlife cognitive deficits and smaller hippocampal volume are risk factors for dementia.

Methods

Participants are members of a representative cohort of 1,037 individuals born in Dunedin, New Zealand, in 1972-1973 and followed to age 45, with 94% retention. Cannabis use and dependence were assessed at ages 18, 21, 26, 32, 38, and 45. IQ was assessed at ages 7, 9, 11, and 45. Specific neuropsychological functions and hippocampal volume were assessed at age 45.

Results

Long-term cannabis users showed IQ decline from childhood to midlife

SUBMITTER: Meier MH 

PROVIDER: S-EPMC9426660 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature