Presence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus-2 on Admission Is Associated With Decreased Mortality in COVID-19 Critical Illness.

ABSTRACT: To determine whether the early serologic response in COVID-19 critical illness is associated with hospital mortality. To evaluate if time-to-seroconversion differs by receipt of dexamethasone therapy.

Design

Patients were prospectively enrolled within 24 hours of ICU admission from two University of Washington Hospitals. Plasma was collected on enrollment and on days 3, 7, 10, and 14.

Setting

ICUs between March 2020 and April 2021.

Patients

Consecutive adults with COVID-19 admitted to an ICU.

Measurements and main results

We measured longitudinal total antispike protein antibody levels (anti-S abs) and total antinucleocapsid antibody levels (anti-N ab) using a U.S. Food and Drug Administration-authorized Roche instrument. We evaluated whether detectable anti-S a

SUBMITTER: Mabrey FL 

PROVIDER: S-EPMC9426803 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature