Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.

ABSTRACT: Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between age and death.

Design

Multicenter cohort study.

Setting

ICUs at 68 hospitals across the United States.

Patients

A total of 5,037 critically ill adults with COVID-19 admitted to ICUs between March 1, 2020, and July 1, 2020.

Interventions

None.

Measurements and main results

The primary exposure was age, modeled as a continuous variable. The primary outcome was 28-day inhospital mortality. Multivariable logistic regression tested the association between age and death. Effect modification by the number of risk factors was assessed

SUBMITTER: Sunderraj A 

PROVIDER: S-EPMC9426819 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature