Identification, conservation, and expression of tiered pharmacogenes in zebrafish.

ABSTRACT: The number of adverse drug events in the United States is critically high, with annual rates exceeding 1 million cases over the last nine years. One cause of adverse drug events is the underlying genetic variation that can alter drug responses. Pharmacogenomics is a growing field that seeks to better understand the relationship between a patient's genetics and drug efficacy. Currently, pharmacogenomics relies largely on human trials, as there is not a well-developed animal model for studying preventative measures and alternative treatments. Here, we analyzed pharmacogene expression at two developmental time points in zebrafish to demonstrate the potential of using this model organism for high-throughput pharmacogenomics research. We found that 76% of tiered human pharmacogenes have a zebra

SUBMITTER: Demery-Poulos C 

PROVIDER: S-EPMC9426904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature