P75NTR prevents the onset of cerebellar granule cell migration via RhoA activation.

ABSTRACT: Neuronal migration is one of the fundamental processes during brain development. Several neurodevelopmental disorders can be traced back to dysregulated migration. Although substantial efforts have been placed in identifying molecular signals that stimulate migration, little is known about potential mechanisms that restrict migration. These restrictive mechanisms are essential for proper development since it helps coordinate the timing for each neuronal population to arrive and establish proper connections. Moreover, preventing migration away from a proliferative niche is necessary in maintaining a pool of proliferating cells until the proper number of neuronal progenitors is attained. Here, using mice and rats, we identify an anti-migratory role for the p75 neurotrophin receptor (p75NTR)

SUBMITTER: Zanin JP 

PROVIDER: S-EPMC9427104 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature