Site-selective, stereocontrolled glycosylation of minimally protected sugars.

ABSTRACT: The identification of general and efficient methods for the construction of oligosaccharides stands as one of the great challenges for the field of synthetic chemistry^1,2. Selective glycosylation of unprotected sugars and other polyhydroxylated nucleophiles is a particularly significant goal, requiring not only control over the stereochemistry of the forming bond but also differentiation between similarly reactive nucleophilic sites in stereochemically complex contexts^3,4. Chemists have generally relied on multi-step protecting-group strategies to achieve site control in glycosylations, but practical inefficiencies arise directly from the application of such approaches^5-7. Here we describe a strategy for small-molecule-catalyst-controlled, highly stereo- an

SUBMITTER: Li Q 

PROVIDER: S-EPMC9427130 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature