Prediction of brain atrophy using three drug scores in neuroasymptomatic HIV-infected patients with controlled viremia.

ABSTRACT:

Background

Despite potent antiretroviral therapy, HIV still causes brain damage. Better penetration into the CNS and efficient elimination of monocyte/macrophages reservoirs are two main characteristics of an antiretroviral drug that could prevent brain damage. The aim of our study was to assess efficacy of three antiretroviral drug scores to predict brain atrophy in HIV-infected patients.

Methods

A cross sectional study consisting of 56 HIV-infected patients with controlled viremia, who had no clinically evident neurocognitive impairment. All patients had MRI of the head. A typical T2 transversal slice was analyzed and ventricles-brain ratio (VBr) as an overall brain atrophy index was calculated. Three antiretroviral drug scores were used and correlated with VBr: 2008 and 2

SUBMITTER: Novakovic M 

PROVIDER: S-EPMC9427456 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature