JC virus/human immunodeficiency virus 1 co-infection in the Brazilian Amazonian region.

ABSTRACT: JC virus (JCV) is a member of the Polyomaviridae family and is associated to a severe disease known as progressive multifocal leukoencephalopathy, PML, which is gradually increasing in incidence as an opportunistic infection among AIDS patients. The present study aimed to investigate the occurrence of JCV among HIV-1 carriers including their types and molecular subtypes and the possible association with disease. Urine samples from 66 HIV-1 infected subjects were investigated for the presence of the virus by amplifying VP1 (215bp) and IG (610bp) regions using the polymerase chain reaction. JCV was detected in 32% of the samples. The results confirmed the occurrence of type B (subtype Af2); in addition, another polyomavirus, BKV, was also detected in 1.5% of samples of the HIV-1 infected sub

SUBMITTER: Cayres-Vallinoto IM 

PROVIDER: S-EPMC9427546 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature