Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population.

ABSTRACT:

Objective

Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study.

Methods

We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested.

Results

Rs1002424 polymorphism showed significant difference in the allele frequencies, but no difference in the genoty

SUBMITTER: Yuan J 

PROVIDER: S-EPMC9427558 | biostudies-literature | 2016 Nov - Dec

REPOSITORIES: biostudies-literature