Diagnostic-driven antifungal therapy in neutropenic patients using the D-index and serial serum galactomannan testing.

ABSTRACT:

Introduction

Invasive mold disease is an important complication of patients with hematologic malignancies, and is associated with high mortality. A diagnostic-driven approach has been an alternative to the classical empiric antifungal therapy. In the present study we tested an algorithm that incorporated risk stratification using the D-index, serial serum galactomannan and computed tomographic-scan to guide the decision to start antifungal therapy in neutropenic patients.

Patients and methods

Between May 2010 and August 2012, patients with acute leukemia in induction remission were prospectively monitored from day 1 of chemotherapy until discharge or death with the D-index and galactomannan. Patients were stratified in low, intermediate and high risk according to the D-index

SUBMITTER: Garnica M 

PROVIDER: S-EPMC9427580 | biostudies-literature | 2016 Jul-Aug

REPOSITORIES: biostudies-literature