Long-term efficacy of proton pump inhibitors as a treatment modality for eosinophilic esophagitis.

ABSTRACT:

Background

Proton pump inhibitors (PPIs) are a first-line treatment for EoE, but data are limited concerning response durability. We aimed to determine long-term outcomes in EoE patients responsive to PPI-therapy.

Methods

We conducted a retrospective cohort study of newly diagnosed adults with EoE who had initial histologic response (<15 eosinophils per high-power-field) to PPI-only therapy. We extracted data regarding their subsequent clinical course and outcomes. We compared findings between the initial PPI-response endoscopy and the final endoscopy, and assessed factors associated with loss of PPI response.

Results

Of 138 EoE patients with initial histologic response to PPI, 50 had long-term endoscopic follow-up, 40 had clinical follow-up, 10 changed treatments, an

SUBMITTER: Thakkar KP 

PROVIDER: S-EPMC9427674 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature