Genomic Risk Score for Advanced Osteoarthritis in Older Adults.

ABSTRACT:

Objective

Prevention of osteoarthritis (OA) remains important, as there are no disease-modifying treatments. A personalized approach has the potential to better target prevention strategies. In the present study, we used recently identified genetic risk variants from genome-wide association analysis for advanced OA to calculate polygenic risk scores (PRS) for knee and hip OA and assessed PRS performance in an independent population of older community-dwelling adults.

Methods

PRS were calculated in 12,093 individuals of European genetic descent ages ≥70 years who were enrolled in the Aspirin in Reducing Events in the Elderly trial. The outcome measure was knee and hip replacement (hospitalizations during the trial and self-reported joint replacements before enrollment). PRS w

SUBMITTER: Lacaze P 

PROVIDER: S-EPMC9427681 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature