EARS2 significantly coexpresses with PALB2 in breast and pancreatic cancer.

ABSTRACT:

Background

PALB2 (BRCA2 partner and localizer) is a BRCA2-interacting protein that is required for BRCA2 genome caretaker tasks and interacts with BRCA1. Women with PALB2 mutation have a 40% to 60% higher risk of breast cancer, almost equivalent to women who have BRCA mutations. PALB2 mutation may also increase the risk of pancreatic cancer. New guidelines for PALB2 mutation in breast cancer advise pancreatic cancer screening, which includes M.R.I.s of the pancreas as well as endoscopic ultrasonography, for women who have a family history of pancreatic cancer. Using the Cancer Genome Atlas (TCGA) and The Human Protein Atlas we examined genes that co-express with PALB2 in breast and pancreatic cancer.

Methods

We used cBioPortal for Cancer Genomics to analyze data in TCGA. cBi

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC9427692 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature