Augmentation of Pulmonary Perfusion by Conducted Effects of a Pulmonary Artery Ultrasound Catheter.

ABSTRACT: Ultrasound (US) generated by catheters used clinically for US-facilitated thrombolysis can release shear-dependent vasodilators from endothelial and red blood cells. We hypothesized that catheter-based US in the pulmonary artery (PA) decreases downstream vascular resistance and increases pulmonary blood flow. In rhesus macaques, a U.S. Food and Drug Administration-approved multi-element US catheter was placed in a pulmonary artery. Comprehensive echocardiography was performed (i) at baseline, (ii) during hypoxemia (12% FIO₂) to increase pulmonary vascular resistance (PVR) and (c) 15 min after initiating US during hypoxemia. Reduced FIO₂ produced intended reductions in oxygen saturation (69 ± 3%) and PaO₂ (34 ± 5 mm Hg), yet on echocardiography, hypoxemia di

SUBMITTER: Muller MA 

PROVIDER: S-EPMC9427700 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature