High-Resolution Elemental Mass Spectrometry Using LC-ICP-Nanospray-Orbitrap for Simultaneous and Species-Independent Quantitation of Fluorinated and Chlorinated Compounds.

ABSTRACT: Simultaneous elemental detection of F and Cl offers quantitation of fluorinated and chlorinated compounds and their transformation products without compound-specific standards. Despite wide-ranging applications, this capability has been hindered by fundamental and technical shortcomings of current inductively coupled plasma (ICP)-MS methods in ion formation and isobaric interference elimination. These hurdles are alleviated here via a chemical ionization method. Fluorine and chlorine in analytes are first converted to HF and HCl by an ICP with post-plasma recombination and subsequently react with barium-containing ions supplied by a nanospray, yielding BaF⁺ and BaCl⁺ as elemental reporter ions. Notably, the method is readily interfaced to an Orbitrap MS which eliminat

SUBMITTER: Redeker FA 

PROVIDER: S-EPMC9427716 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature