Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.

ABSTRACT:

Background

Abnormalities in Ca²⁺ homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca²⁺ homeostasis in cardiomyocytes. Alternative splicing of a single triadin gene produces multiple triadin isoforms. The cardiac-predominant isoform, mouse MT-1 or human Trisk32, is encoded by triadin exons 1 to 8. In humans, mutations in the triadin gene that lead to a reduction in Trisk32 levels in the heart can cause cardiac dysfunction and arrhythmias. Decreased levels of Trisk32 in the heart are also common in patients with heart failure. However, mechanisms that maintain triadin isoform composition in the heart remain elusive.

Methods

We analyzed triadin expression in heart explants from p

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9427731 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature