High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes.

ABSTRACT: Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic options over a long period. It is generally considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor, namely G protein-coupled estrogen receptor (GPER), is demonstrated to mediate estrogenic actions in TNBC. Based on our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables and survival of 360 TNBC patients. GPER expression at mRNA level was significantly correlated with immunohistochemistry scoring in 12 randomly chosen samples. According to the cutoff value, 26.4% (95/360) of patients showed high GPER expression and significant correlation with the mRNA subtyp

SUBMITTER: Xu T 

PROVIDER: S-EPMC9427744 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature