Elevated KIR expression and diminished intensity of CD7 on NK cell subsets among treatment naive HIV infected Ethiopians.

ABSTRACT: Natural killer (NK) cells are crucial effector cells of the innate immune response to viral infections, including HIV, through cytolytic activity and the production of cytokines with anti-HIV activities. We recruited 15 treatment naïve HIV patients and 16 healthy controls (HC) to assess NK cell subsets or expression of multiple markers by flow cytometry. The frequency of circulating CD56^brightCD16^-ve and CD56^dimCD16^bright NK cell subsets was significantly lower among the HIV group than in HC. The CD56^-veCD16^bright subset was higher in HIV patients, but this was only apparent when gated among total NK cells, not total lymphocytes. NK cells among HIV participants also showed a lower and higher frequency of CD8 and HLA-DR expre

SUBMITTER: Andualem H 

PROVIDER: S-EPMC9427747 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature