CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response.

ABSTRACT: The cell adhesion molecule CD44 has been implicated in diverse biological functions including the pathological responses to infections and inflammatory diseases. The variable forms of CD44 contribute to functional variations, which are not yet defined in teleost. Here, we show that zebrafish CD44a plays a protective role in the host defense against Edwardsiella piscicida infection. Zebrafish CD44a deficiency inhibits cell growth and proliferation, impairs cell growth and death pathways, and regulates the expression levels of many genes involved in p53 signaling, apoptosis and autophagy. In addition, CD44a gene disruption in zebrafish leads to inhibition of apoptosis and induction of autophagy, with the increased susceptibility to E. piscicida infection. Furthermore, we show that zebrafish

SUBMITTER: Cao L 

PROVIDER: S-EPMC9427754 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature