Dynamic changes in longitudinal circulating tumour DNA profile during metastatic colorectal cancer treatment.

ABSTRACT:

Background

Circulating tumour DNA (ctDNA) has been spotlighted as an attractive biomarker because of its easy accessibility and real-time representation of tumour genetic profile. However, the clinical utility of longitudinal ctDNA monitoring has not been clearly defined.

Methods

Serial blood samples were obtained from metastatic colorectal cancer patients undergoing first-line chemotherapy. ctDNA was sequenced using a targeted next-generation sequencing platform which included 106 genes. Changes in ctDNA profile and treatment outcome were comprehensively analysed.

Results

A total of 272 samples from 62 patients were analysed. In all, 90.3% of patients had detectable ctDNA mutation before treatment. ctDNA clearance after chemotherapy was associated with longer progres

SUBMITTER: Kim S 

PROVIDER: S-EPMC9427785 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature