The Ntan1 gene is expressed in perineural glia and neurons of adult Drosophila.

ABSTRACT: The Drosophila Ntan1 gene encodes an N-terminal asparagine amidohydrolase that we show is highly conserved throughout evolution. Protein isoforms share more than 72% of similarity with their human counterparts. At the cellular level, this gene regulates the type of glial cell growth in Drosophila larvae by its different expression levels. The Drosophila Ntan1 gene has 4 transcripts that encode 2 protein isoforms. Here we describe that although this gene is expressed at all developmental stages and adult organs tested (eye, antennae and brain) there are some transcript-dependent specificities. Therefore, both quantitative and qualitative cues could account for gene function. However, widespread developmental stage and organ-dependent expression could be masking cell-specific constraints tha

SUBMITTER: Castaneda-Sampedro A 

PROVIDER: S-EPMC9427837 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature