Mapping the association between tau-PET and Aβ-amyloid-PET using deep learning.

ABSTRACT: In Alzheimer's disease, the molecular pathogenesis of the extracellular Aβ-amyloid (Aβ) instigation of intracellular tau accumulation is poorly understood. We employed a high-resolution PET scanner, with low detection thresholds, to examine the Aβ-tau association using a convolutional neural network (CNN), and compared results to a standard voxel-wise linear analysis. The full range of Aβ Centiloid values was highly predicted by the tau topography using the CNN (training R² = 0.86, validation R² = 0.75, testing R² = 0.72). Linear models based on tau-SUVR identified widespread positive correlations between tau accumulation and Aβ burden throughout the brain. In contrast, CNN analysis identified focal clusters in the bilateral medial temporal lobes, frontal l

SUBMITTER: Ruwanpathirana GP 

PROVIDER: S-EPMC9427855 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature