Oncological and functional outcomes after testis-sparing surgery in patients with germ cell tumors: a systematic review of 285 cases.

ABSTRACT:

Introduction and objectives

In several urogenital cancers, organ-preserving surgery represents the preferred treatment approach, but in patients with testicular germ cell tumors (tGCTs), radical orchiectomy represents the standard of care. This study aimed to summarize published case series assessing oncological and functional outcomes after testis-sparing surgery (TSS) in patients with tGCTs.

Materials and methods

A systematic literature review and individual patient data meta-analysis were conducted of published cases with tGCT treated with TSS.

Results

Of 2,333 reports, we included 32 reports providing data on 285 patients, including 306 testicles treated with TSS. Adjacent germ cell neoplasia in situ (GCNIS) was described in 43%. Hypogonadism and infertility after

SUBMITTER: Grogg JB 

PROVIDER: S-EPMC9427883 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature