Tapinarof Cream 1%: First Approval.

ABSTRACT: Tapinarof cream 1% (VTAMA^®) is an aryl hydrocarbon receptor (AhR) agonist that is being developed by Dermavant Sciences Inc. (a subsidiary of Roivant Sciences Inc.) as a once-daily topical treatment for plaque psoriasis and atopic dermatitis. AhR is a ligand-dependent transcription factor that has a role in immune-mediated skin responses. In May 2022, tapinarof cream 1% was approved in the USA for the topical treatment of plaque psoriasis in adults. Tapinarof cream 1% is also being investigated for the treatment of atopic dermatitis. This article summarizes the milestones in the development of tapinarof cream 1% leading to this first approval for the topical treatment of plaque psoriasis.

SUBMITTER: Keam SJ 

PROVIDER: S-EPMC9427914 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature