Decreased NHE3 expression in colon cancer is associated with DNA damage, increased inflammation and tumor growth.

ABSTRACT: Dysregulation of intra- and extracellular pH in cancer contributes to extracellular matrix remodeling, favors cell migration, proliferation, and metastasis. Although the primary attention has been focused on the role of the ubiquitous Na⁺/H⁺ exchanger isoform NHE1, the role of NHE3, the predominant apical isoform in colonic surface epithelium in the pathogenesis of colon cancer has not been investigated. Here, we show that NHE3 mRNA expression is significantly reduced in colorectal cancer patients and that low NHE3 expression is associated with poorer survival. Deletion of NHE3 in Apc^Min mice evaluated at 15 weeks of age (significant mortality was observed beyond this time) led to lower body weights, increased mucosal inflammation, increased colonic tumor n

SUBMITTER: Laubitz D 

PROVIDER: S-EPMC9427942 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature