Antipsychotic-induced weight gain and metabolic effects show diurnal dependence and are reversible with time restricted feeding.

ABSTRACT: Antipsychotic drugs (AP) are highly efficacious treatments for psychiatric disorders but are associated with significant metabolic side-effects. The circadian clock maintains metabolic homeostasis by sustaining daily rhythms in feeding, fasting and hormone regulation but how circadian rhythms interact with AP and its associated metabolic side-effects is not well-known. We hypothesized that time of AP dosing impacts the development of metabolic side-effects. Weight gain and metabolic side-effects were compared in C57Bl/6 mice and humans dosed with APs in either the morning or evening. In mice, AP dosing at the start of the light cycle/rest period (AM) resulted in significant increase in food intake and weight gain compared with equivalent dose before the onset of darkness/active period (PM)

SUBMITTER: Zapata RC 

PROVIDER: S-EPMC9427943 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature