Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism.

ABSTRACT:

Aim

To analyze the influence of the -31 C/T polymorphism of the interleukin-1β gene on Helicobacter pylori eradication therapy success in patients with functional dyspepsia.

Methods

Functional dyspepsia was diagnosed according to the Rome III criteria. All patients underwent upper gastrointestinal endoscopy, and gastric biopsies were obtained at screening and 12 months after randomization (last follow-up visit). Urease test and histological examination were performed to define the H. pylori status. Patients received twice-daily amoxicillin, clarithromycin and omeprazole for 10 days. Genotyping of the interleukin-1beta -31 C/T polymorphism (rs1143627) was performed using polymerase chain reaction-restriction fragment length polymorphism.

Results

One hundred forty-nine

SUBMITTER: Rech TF 

PROVIDER: S-EPMC9428014 | biostudies-literature | 2018 Jul - Aug

REPOSITORIES: biostudies-literature