Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica.

ABSTRACT:

Objectives

To study the potential factors include gene mutation, efflux pump and alteration of permeability associated with quinolone-resistance of Salmonella enterica strains isolated from patients with acute gastroenteritis and to evaluate the degree of synergistic activity of efflux pump inhibitors when combined with ciprofloxacin against resistant isolates.

Methods

Antimicrobial resistance patterns of fifty-eight Salmonella isolates were tested. Five isolates were selected to study the mechanism of resistance associated with quinolone group, including mutation in topoisomerase-encoding gene, altered cell permeability, and expression of an active efflux system. In addition, the combination between antibiotics and efflux pump inhibitors to overcome the microbial resistance

SUBMITTER: Rushdy AA 

PROVIDER: S-EPMC9428056 | biostudies-literature | 2013 Jul-Aug

REPOSITORIES: biostudies-literature